The tuber of Pinellia ternata Breitenbach(Araceae), which is distributed in Korea, China, and Japan, has been used in traditional Chinese medicine. The prescription containing Pinellia tuber shows anti-emetic, sedative, and anti-tussive effects. The purpose of this study was to investigate the effects of Pinellia ternata tuber on the xylazine-induced emetic and sedative responses in cats.
The results were as follows ;
1. Intramuscular injection of xylazine hydrochloride (1.0㎎/㎏) reliably evoked vomiting with an incidence of 100% and sedated with a mean sedation time of 34.22 min.
2. The xylazine-induced emetic and sedative responses were not prevented by oral administration of powder ( 0.5g/head ) , decoction (1.0㎖ /100g) , and methanol extract (0.1㎖/100g ) of the Pinellia temata tuber.
3. The xylazine-induced emetic and sedative responses were inhibited by intravenous injection of decoction(0.3㎖/100g) of the Pinellia temata tuber.
4. The xylazine-induced emetic and sedative responses were inhibited by intravenous injection of a combined mixture of yohimbine hydrochloride(0.125㎎/㎏) and 4-aminopyride(0.3㎎/㎏).
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